EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques

Alzheimer's disease (AD) is characterized by the transition of amyloid-β (Aβ) monomers into toxic oligomers and plaques. Given that Aβ abnormality typically precedes the development of clinical symptoms, an agent capable of disaggregating existing Aβ aggregates may be advantageous. Here we repo...

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Detalles Bibliográficos
Autores principales: Kim, Hye Yun, Kim, Hyunjin Vincent, Jo, Seonmi, Lee, C. Justin, Choi, Seon Young, Kim, Dong Jin, Kim, YoungSoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686862/
https://www.ncbi.nlm.nih.gov/pubmed/26646366
http://dx.doi.org/10.1038/ncomms9997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686862/
https://www.ncbi.nlm.nih.gov/pubmed/26646366
http://dx.doi.org/10.1038/ncomms9997

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