Peptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1

Chemokine CXCL8 is crucial for regulation of inflammatory and immune responses via activating its cognate receptor CXCR1. In this study, molecular docking and binding free energy calculations were combined to predict the initial binding event of CXCL8 to CXCR1 for peptide drug design. The simulation...

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Detalles Bibliográficos
Autores principales: Jiang, Shinn-Jong, Liou, Je-Wen, Chang, Chun-Chun, Chung, Yi, Lin, Lee-Fong, Hsu, Hao-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686899/
https://www.ncbi.nlm.nih.gov/pubmed/26689258
http://dx.doi.org/10.1038/srep18638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686899/
https://www.ncbi.nlm.nih.gov/pubmed/26689258
http://dx.doi.org/10.1038/srep18638

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