Nobiletin enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cancer cells

Multidrug resistance (MDR) is the major obstacle to the successful chemotherapy treatment of many cancers. Here we found that nobiletin, a citrus methoxyflavone, significantly sensitized ABCB1 overexpressing cells A2780/T and A549/T to chemotherapeutic agents such as paclitaxel (a 433-fold reversal...

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Detalles Bibliográficos
Autores principales: Ma, Wenzhe, Feng, Senling, Yao, Xiaojun, Yuan, Zhongwen, Liu, Liang, Xie, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686932/
https://www.ncbi.nlm.nih.gov/pubmed/26689156
http://dx.doi.org/10.1038/srep18789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686932/
https://www.ncbi.nlm.nih.gov/pubmed/26689156
http://dx.doi.org/10.1038/srep18789

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