High Glucose–Repressed CITED2 Expression Through miR-200b Triggers the Unfolded Protein Response and Endoplasmic Reticulum Stress

High glucose in vivo and in vitro induces neural tube defects (NTDs). CITED2 (CBP/p300-interacting transactivator with ED-rich tail 2) is essential for neural tube closure. We explored the regulatory mechanism underlying CITED2 expression and its relationship with miRNA and endoplasmic reticulum (ER...

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Detalles Bibliográficos
Autores principales: Gu, Hui, Yu, Jingwen, Dong, Daoyin, Zhou, Qun, Wang, Jian-Ying, Fang, Shengyun, Yang, Peixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Pathophysiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686950/
https://www.ncbi.nlm.nih.gov/pubmed/26450995
http://dx.doi.org/10.2337/db15-0108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686950/
https://www.ncbi.nlm.nih.gov/pubmed/26450995
http://dx.doi.org/10.2337/db15-0108

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