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Local Geometry and Evolutionary Conservation of Protein Surfaces Reveal the Multiple Recognition Patches in Protein-Protein Interactions

Protein-protein interactions (PPIs) are essential to all biological processes and they represent increasingly important therapeutic targets. Here, we present a new method for accurately predicting protein-protein interfaces, understanding their properties, origins and binding to multiple partners. C...

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Detalles Bibliográficos
Autores principales: Laine, Elodie, Carbone, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686965/
https://www.ncbi.nlm.nih.gov/pubmed/26690684
http://dx.doi.org/10.1371/journal.pcbi.1004580