Beclin 1 regulates neuronal transforming growth factor-β signaling by mediating recycling of the type I receptor ALK5

BACKGROUND: Beclin 1 is a key regulator of multiple trafficking pathways, including autophagy and receptor recycling in yeast and microglia. Decreased beclin 1 levels in the CNS result in neurodegeneration, an effect attributed to impaired autophagy. However, neurons also rely heavily on trophic fac...

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Detalles Bibliográficos
Autores principales: O’Brien, Caitlin E., Bonanno, Liana, Zhang, Hui, Wyss-Coray, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687091/
https://www.ncbi.nlm.nih.gov/pubmed/26692002
http://dx.doi.org/10.1186/s13024-015-0065-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687091/
https://www.ncbi.nlm.nih.gov/pubmed/26692002
http://dx.doi.org/10.1186/s13024-015-0065-0

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