Genome editing through large insertion leads to the skipping of targeted exon

BACKGROUND: Highly efficient genome editing can be achieved through targeting an endonuclease to specific locus of interest. Engineered zinc-finger nuclease (ZFN) and CRISPR-associated protein-9 nuclease (Cas9) offer such an elegant approach for genome editing in vertebrate cells. In this study, we...

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Detalles Bibliográficos
Autores principales: Uddin, Borhan, Chen, Nan-Peng, Panic, Marko, Schiebel, Elmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687116/
https://www.ncbi.nlm.nih.gov/pubmed/26691863
http://dx.doi.org/10.1186/s12864-015-2284-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687116/
https://www.ncbi.nlm.nih.gov/pubmed/26691863
http://dx.doi.org/10.1186/s12864-015-2284-8

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