A Multi Targeting Conditionally Replicating Adenovirus Displays Enhanced Oncolysis while Maintaining Expression of Immunotherapeutic Agents

Studies have demonstrated that oncolytic adenoviruses based on a 24 base pair deletion in the viral E1A gene (D24) may be promising therapeutics for treating a number of cancer types. In order to increase the therapeutic potential of these oncolytic viruses, a novel conditionally replicating adenovi...

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Detalles Bibliográficos
Autores principales: Dobbins, G. Clement, Ugai, Hideyo, Curiel, David T., Gillespie, G. Yancey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687127/
https://www.ncbi.nlm.nih.gov/pubmed/26689910
http://dx.doi.org/10.1371/journal.pone.0145272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687127/
https://www.ncbi.nlm.nih.gov/pubmed/26689910
http://dx.doi.org/10.1371/journal.pone.0145272

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