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PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug

BACKGROUND: Many promising anticancer molecules are abandoned during the course from bench to bedside due to lack of clear-cut efficiency and/or severe side effects. Vitamin K3 (vitK3) is a synthetic naphthoquinone exhibiting significant in vitro and in vivo anticancer activity against multiple huma...

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Detalles Bibliográficos
Autores principales: He, Tiantian, Hatem, Elie, Vernis, Laurence, Lei, Ming, Huang, Meng-Er
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687332/
https://www.ncbi.nlm.nih.gov/pubmed/26689287
http://dx.doi.org/10.1186/s13046-015-0270-2