Exogenous spermine inhibits the proliferation of human pulmonary artery smooth muscle cells caused by chemically-induced hypoxia via the suppression of the ERK1/2- and PI3K/AKT-associated pathways

Pulmonary vascular remodeling is a significant pathological feature of hypoxia-induced pulmonary hypertension (HPH), while pulmonary artery smooth muscle cell (PASMC) proliferation plays a leading role in pulmonary vascular remodeling. Spermine (Sp), a polyamine, plays a critical role in periodic ce...

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Detalles Bibliográficos
Autores principales: WEI, CAN, LI, HONG-ZHU, WANG, YUE-HONG, PENG, XUE, SHAO, HONG-JIANG, LI, HONG-XIA, BAI, SHU-ZHI, LU, XIAO-XIAO, WU, LING-YUN, WANG, RUI, XU, CHANG-QING
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687431/
https://www.ncbi.nlm.nih.gov/pubmed/26572277
http://dx.doi.org/10.3892/ijmm.2015.2408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687431/
https://www.ncbi.nlm.nih.gov/pubmed/26572277
http://dx.doi.org/10.3892/ijmm.2015.2408

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