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Exogenous spermine inhibits the proliferation of human pulmonary artery smooth muscle cells caused by chemically-induced hypoxia via the suppression of the ERK1/2- and PI3K/AKT-associated pathways

Pulmonary vascular remodeling is a significant pathological feature of hypoxia-induced pulmonary hypertension (HPH), while pulmonary artery smooth muscle cell (PASMC) proliferation plays a leading role in pulmonary vascular remodeling. Spermine (Sp), a polyamine, plays a critical role in periodic ce...

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Detalles Bibliográficos
Autores principales:	WEI, CAN, LI, HONG-ZHU, WANG, YUE-HONG, PENG, XUE, SHAO, HONG-JIANG, LI, HONG-XIA, BAI, SHU-ZHI, LU, XIAO-XIAO, WU, LING-YUN, WANG, RUI, XU, CHANG-QING
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687431/ https://www.ncbi.nlm.nih.gov/pubmed/26572277 http://dx.doi.org/10.3892/ijmm.2015.2408

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