Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity

ApoE deficiency in mice (Apoe (−/−)) results in severe hypercholesterolemia and atherosclerosis. In diet-induced obesity, Apoe (−/−) display steatohepatitis but reduced accumulation of triacylglycerides and enhanced insulin sensitivity in white adipose tissue (WAT). Although the vast majority of apo...

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Detalles Bibliográficos
Autores principales: Wagner, Tobias, Bartelt, Alexander, Schlein, Christian, Heeren, Joerg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687855/
https://www.ncbi.nlm.nih.gov/pubmed/26695075
http://dx.doi.org/10.1371/journal.pone.0145102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687855/
https://www.ncbi.nlm.nih.gov/pubmed/26695075
http://dx.doi.org/10.1371/journal.pone.0145102

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