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Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity

ApoE deficiency in mice (Apoe (−/−)) results in severe hypercholesterolemia and atherosclerosis. In diet-induced obesity, Apoe (−/−) display steatohepatitis but reduced accumulation of triacylglycerides and enhanced insulin sensitivity in white adipose tissue (WAT). Although the vast majority of apo...

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Detalles Bibliográficos
Autores principales:	Wagner, Tobias, Bartelt, Alexander, Schlein, Christian, Heeren, Joerg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687855/ https://www.ncbi.nlm.nih.gov/pubmed/26695075 http://dx.doi.org/10.1371/journal.pone.0145102

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