Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis
Many single-transmembrane proteins are sequentially cleaved by ectodomain-shedding α-secretases and the γ-secretase complex, a process called regulated intramembrane proteolysis (RIP). These cleavages are thought to be spatially and temporally separate. In contrast, we provide evidence for a hithert...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687875/ https://www.ncbi.nlm.nih.gov/pubmed/26694839 http://dx.doi.org/10.1083/jcb.201502001 |