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Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis

Many single-transmembrane proteins are sequentially cleaved by ectodomain-shedding α-secretases and the γ-secretase complex, a process called regulated intramembrane proteolysis (RIP). These cleavages are thought to be spatially and temporally separate. In contrast, we provide evidence for a hithert...

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Detalles Bibliográficos
Autores principales:	Chen, Allen C., Kim, Sumin, Shepardson, Nina, Patel, Sarvagna, Hong, Soyon, Selkoe, Dennis J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687875/ https://www.ncbi.nlm.nih.gov/pubmed/26694839 http://dx.doi.org/10.1083/jcb.201502001

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