Flunarizine prevents hepatitis C virus membrane fusion in a genotype‐dependent manner by targeting the potential fusion peptide within E1

To explore mechanisms of hepatitis C viral (HCV) replication we screened a compound library including licensed drugs. Flunarizine, a diphenylmethylpiperazine used to treat migraine, inhibited HCV cell entry in vitro and in vivo in a genotype‐dependent fashion. Analysis of mosaic viruses between susc...

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Detalles Bibliográficos
Autores principales: Perin, Paula M., Haid, Sibylle, Brown, Richard J.P., Doerrbecker, Juliane, Schulze, Kai, Zeilinger, Carsten, von Schaewen, Markus, Heller, Brigitte, Vercauteren, Koen, Luxenburger, Eva, Baktash, Yasmine M., Vondran, Florian W.R., Speerstra, Sietkse, Awadh, Abdullah, Mukhtarov, Furkat, Schang, Luis M., Kirschning, Andreas, Müller, Rolf, Guzman, Carlos A., Kaderali, Lars, Randall, Glenn, Meuleman, Philip, Ploss, Alexander, Pietschmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Viral Hepatitis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688136/
https://www.ncbi.nlm.nih.gov/pubmed/26248546
http://dx.doi.org/10.1002/hep.28111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688136/
https://www.ncbi.nlm.nih.gov/pubmed/26248546
http://dx.doi.org/10.1002/hep.28111

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