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Distinctive Behaviors of Druggable Proteins in Cellular Networks

The interaction environment of a protein in a cellular network is important in defining the role that the protein plays in the system as a whole, and thus its potential suitability as a drug target. Despite the importance of the network environment, it is neglected during target selection for drug d...

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Detalles Bibliográficos
Autores principales: Mitsopoulos, Costas, Schierz, Amanda C., Workman, Paul, Al-Lazikani, Bissan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689399/
https://www.ncbi.nlm.nih.gov/pubmed/26699810
http://dx.doi.org/10.1371/journal.pcbi.1004597