2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity

We have screened our compound collection in an established cell based assay that measures the derepression of an epigenetically silenced transgene, the locus derepression assay. The screen led to the identification of 4-[4-(1-methylbenzimidazol-2-yl)piperazin-1-yl]sulfonylbenzenecarbohydroxamic acid...

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Detalles Bibliográficos
Autores principales: Wang, Lei, Kofler, Marina, Brosch, Gerald, Melesina, Jelena, Sippl, Wolfgang, Martinez, Elisabeth D., Easmon, Johnny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689404/
https://www.ncbi.nlm.nih.gov/pubmed/26698121
http://dx.doi.org/10.1371/journal.pone.0134556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689404/
https://www.ncbi.nlm.nih.gov/pubmed/26698121
http://dx.doi.org/10.1371/journal.pone.0134556

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