Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans

BACKGROUND AND PURPOSE: The selection of the most suitable animal species and subsequent translation of the concentration-effect relationship to humans are critical steps for accurate assessment of the pro-arrhythmic risk of candidate molecules. The objective of this investigation was to assess quan...

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Detalles Bibliográficos
Autores principales: Dubois, V. F. S., de Witte, W. E. A., Visser, S. A. G., Danhof, M., Della Pasqua, O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689776/
https://www.ncbi.nlm.nih.gov/pubmed/26553352
http://dx.doi.org/10.1007/s11095-015-1760-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689776/
https://www.ncbi.nlm.nih.gov/pubmed/26553352
http://dx.doi.org/10.1007/s11095-015-1760-9

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