Mutations in the Voltage Sensors of Domains I and II of Na(v)1.5 that are Associated with Arrhythmias and Dilated Cardiomyopathy Generate Gating Pore Currents

Voltage gated sodium channels (Na(v)) are transmembrane proteins responsible for action potential initiation. Mutations mainly located in the voltage sensor domain (VSD) of Na(v)1.5, the cardiac sodium channel, have been associated with the development of arrhythmias combined with dilated cardiomyop...

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Detalles Bibliográficos
Autores principales: Moreau, Adrien, Gosselin-Badaroudine, Pascal, Boutjdir, Mohamed, Chahine, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689871/
https://www.ncbi.nlm.nih.gov/pubmed/26733869
http://dx.doi.org/10.3389/fphar.2015.00301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689871/
https://www.ncbi.nlm.nih.gov/pubmed/26733869
http://dx.doi.org/10.3389/fphar.2015.00301

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