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Mutations in the Voltage Sensors of Domains I and II of Na(v)1.5 that are Associated with Arrhythmias and Dilated Cardiomyopathy Generate Gating Pore Currents
Voltage gated sodium channels (Na(v)) are transmembrane proteins responsible for action potential initiation. Mutations mainly located in the voltage sensor domain (VSD) of Na(v)1.5, the cardiac sodium channel, have been associated with the development of arrhythmias combined with dilated cardiomyop...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689871/ https://www.ncbi.nlm.nih.gov/pubmed/26733869 http://dx.doi.org/10.3389/fphar.2015.00301 |