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An efficient strategy for generation of transgenic mice by lentiviral transduction of male germline stem cells in vivo
BACKGROUND: Male germline stem cells (MGSCs) are a subpopulation of germ cells in the testis tissue. MGSCs are capable of differentiation into spermatozoa and thus are perfect targets for genomic manipulation to generate transgenic animals. METHOD: The present study was to optimize a protocol of pro...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690335/ https://www.ncbi.nlm.nih.gov/pubmed/26705472 http://dx.doi.org/10.1186/s40104-015-0058-4 |