Differential scanning calorimetry of whole Escherichia coli treated with the antimicrobial peptide MSI-78 indicate a multi-hit mechanism with ribosomes as a novel target

Differential Scanning Calorimetry (DSC) of intact Escherichia coli (E. coli) was used to identify non-lipidic targets of the antimicrobial peptide (AMP) MSI-78. The DSC thermograms revealed that, in addition to its known lytic properties, MSI-78 also has a striking effect on ribosomes. MSI-78’s effe...

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Detalles Bibliográficos
Autores principales: Brannan, Alexander M., Whelan, William A., Cole, Emma, Booth, Valerie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2015
Materias:
Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690349/
https://www.ncbi.nlm.nih.gov/pubmed/26713257
http://dx.doi.org/10.7717/peerj.1516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690349/
https://www.ncbi.nlm.nih.gov/pubmed/26713257
http://dx.doi.org/10.7717/peerj.1516

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