Fingolimod (FTY720-P) Does Not Stabilize the Blood–Brain Barrier under Inflammatory Conditions in an in Vitro Model

Breakdown of the blood-brain barrier (BBB) is an early hallmark of multiple sclerosis (MS), a progressive inflammatory disease of the central nervous system. Cell adhesion in the BBB is modulated by sphingosine-1-phosphate (S1P), a signaling protein, via S1P receptors (S1P(1)). Fingolimod phosphate...

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Detalles Bibliográficos
Autores principales: Schuhmann, Michael K., Bittner, Stefan, Meuth, Sven G., Kleinschnitz, Christoph, Fluri, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691120/
https://www.ncbi.nlm.nih.gov/pubmed/26690412
http://dx.doi.org/10.3390/ijms161226177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691120/
https://www.ncbi.nlm.nih.gov/pubmed/26690412
http://dx.doi.org/10.3390/ijms161226177

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