Combination Treatment with Sublethal Ionizing Radiation and the Proteasome Inhibitor, Bortezomib, Enhances Death-Receptor Mediated Apoptosis and Anti-Tumor Immune Attack

Sub-lethal doses of radiation can modulate gene expression, making tumor cells more susceptible to T-cell-mediated immune attack. Proteasome inhibitors demonstrate broad anti-tumor activity in clinical and pre-clinical cancer models. Here, we use a combination treatment of proteasome inhibition and...

Descripción completa

Detalles Bibliográficos
Autores principales: Cacan, Ercan, Spring, Alexander M., Kumari, Anita, Greer, Susanna F., Garnett-Benson, Charlie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691179/
https://www.ncbi.nlm.nih.gov/pubmed/26703577
http://dx.doi.org/10.3390/ijms161226238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691179/
https://www.ncbi.nlm.nih.gov/pubmed/26703577
http://dx.doi.org/10.3390/ijms161226238

Ejemplares similares