FoxO1-Dependent Induction of Acute Myeloid Leukemia by Osteoblasts in Mice

Osteoblasts, the bone forming cells, affect self-renewal and expansion of hematopoietic stem cells (HSCs), as well as homing of healthy hematopoietic cells and tumor cells into the bone marrow. Constitutive activation of β-catenin in osteoblasts is sufficient to alter the differentiation potential o...

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Detalles Bibliográficos
Autores principales: Kode, Aruna, Mosialou, Ioanna, Manavalan, Sanil J., Rathinam, Choza V., Friedman, Richard A., Teruya-Feldstein, Julie, Bhagat, Govind, Berman, Ellin, Kousteni, Stavroula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691220/
https://www.ncbi.nlm.nih.gov/pubmed/26108693
http://dx.doi.org/10.1038/leu.2015.161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691220/
https://www.ncbi.nlm.nih.gov/pubmed/26108693
http://dx.doi.org/10.1038/leu.2015.161

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