Unraveling the B. pseudomallei Heptokinase WcbL: From Structure to Drug Discovery

Gram-negative bacteria utilize heptoses as part of their repertoire of extracellular polysaccharide virulence determinants. Disruption of heptose biosynthesis offers an attractive target for novel antimicrobials. A critical step in the synthesis of heptoses is their 1-O phosphorylation, mediated by...

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Detalles Bibliográficos
Autores principales: Vivoli, Mirella, Isupov, Michail N., Nicholas, Rebecca, Hill, Andrew, Scott, Andrew E., Kosma, Paul, Prior, Joann L., Harmer, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691232/
https://www.ncbi.nlm.nih.gov/pubmed/26687481
http://dx.doi.org/10.1016/j.chembiol.2015.10.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691232/
https://www.ncbi.nlm.nih.gov/pubmed/26687481
http://dx.doi.org/10.1016/j.chembiol.2015.10.015

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