Cargando…

Unraveling the B. pseudomallei Heptokinase WcbL: From Structure to Drug Discovery

Gram-negative bacteria utilize heptoses as part of their repertoire of extracellular polysaccharide virulence determinants. Disruption of heptose biosynthesis offers an attractive target for novel antimicrobials. A critical step in the synthesis of heptoses is their 1-O phosphorylation, mediated by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vivoli, Mirella, Isupov, Michail N., Nicholas, Rebecca, Hill, Andrew, Scott, Andrew E., Kosma, Paul, Prior, Joann L., Harmer, Nicholas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691232/ https://www.ncbi.nlm.nih.gov/pubmed/26687481 http://dx.doi.org/10.1016/j.chembiol.2015.10.015

Ejemplares similares

Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme
por: Vivoli, Mirella, et al.
Publicado: (2013)

Spinning sugars in antigen biosynthesis: characterization of the Coxiella burnetii and Streptomyces griseus TDP-sugar epimerases
por: Cross, Alice R., et al.
Publicado: (2022)

The ROK kinase N-acetylglucosamine kinase uses a sequential random enzyme mechanism with successive conformational changes upon each substrate binding
por: Roy, Sumita, et al.
Publicado: (2023)

A half-site multimeric enzyme achieves its cooperativity without conformational changes
por: Vivoli, Mirella, et al.
Publicado: (2017)

Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry
por: Vivoli, Mirella, et al.
Publicado: (2014)

Genome Resequencing of Laboratory Stocks of Burkholderia pseudomallei K96243
por: Wagley, Sariqa, et al.
Publicado: (2019)

The Arabinose 5-Phosphate Isomerase KdsD Is Required for Virulence in Burkholderia pseudomallei
por: Jenkins, Christopher H., et al.
Publicado: (2023)

Determining the influence of the Workers Compensation Board of Manitoba's opioid policy on prescription opioid use amongst WCB recipients
por: Kraut, Allen, et al.
Publicado: (2020)

A comparison of opioid use between WCB recipients and other Manitobans for knee, shoulder, back and carpal tunnel release procedures
por: Kraut, Allen, et al.
Publicado: (2016)

Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR
por: Freda, Ida, et al.
Publicado: (2023)

In Vitro Priming of Human T Cells by Dendritic Cells Provides a Screening Tool for Candidate Vaccines for Burkholderia pseudomallei
por: Reddi, Durga, et al.
Publicado: (2021)

The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation
por: Butt, Aaron, et al.
Publicado: (2014)

Identification of a Predicted Trimeric Autotransporter Adhesin Required for Biofilm Formation of Burkholderia pseudomallei
por: Lazar Adler, Natalie R., et al.
Publicado: (2013)

Correction: Identification of a Predicted Trimeric Autotransporter Adhesin Required for Biofilm Formation of Burkholderia pseudomallei
por: Lazar Adler, Natalie R., et al.
Publicado: (2014)

Structural characterisation of the capsular polysaccharide expressed by Burkholderia thailandensis strain E555:: wbiI (pKnock-KmR) and assessment of the significance of the 2-O-acetyl group in immune protection
por: Bayliss, Marc, et al.
Publicado: (2017)

Structural characterization of a novel cyclic 2,3-diphosphoglycerate synthetase involved in extremolyte production in the archaeon Methanothermus fervidus
por: De Rose, Simone A., et al.
Publicado: (2023)

Sequence- and Structure-Based Immunoreactive Epitope Discovery for Burkholderia pseudomallei Flagellin
por: Nithichanon, Arnone, et al.
Publicado: (2015)

Burkholderia pseudomallei Antibodies in Children, Cambodia
por: Wuthiekanun, Vanaporn, et al.
Publicado: (2008)

Differential Toll-Like Receptor-Signalling of Burkholderia pseudomallei Lipopolysaccharide in Murine and Human Models
por: Weehuizen, Tassili A. F., et al.
Publicado: (2015)

Structural and biochemical characterisation of Archaeoglobus fulgidus esterase reveals a bound CoA molecule in the vicinity of the active site
por: Sayer, Christopher, et al.
Publicado: (2016)

Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection
por: Cizmeci, Deniz, et al.
Publicado: (2016)

The Burkholderia pseudomallei intracellular ‘TRANSITome’
por: Heacock-Kang, Yun, et al.
Publicado: (2021)

Seroepidemiological surveillance of Burkholderia pseudomallei in Bangladesh
por: Maude, Rapeephan R., et al.
Publicado: (2012)

Genetic Diversity and Microevolution of Burkholderia pseudomallei in the Environment
por: Chantratita, Narisara, et al.
Publicado: (2008)

Burkholderia thailandensis strain E555 is a surrogate for the investigation of Burkholderia pseudomallei replication and survival in macrophages
por: Kovacs-Simon, A., et al.
Publicado: (2019)

Failure of Burkholderia pseudomallei to Grow in an Automated Blood Culture System
por: Teerawattanasook, Nittaya, et al.
Publicado: (2014)

Zoonoses under our noses
por: Cross, Alice R., et al.
Publicado: (2019)

Survival of Burkholderia pseudomallei in distilled water for 16 years
por: Pumpuang, Apinya, et al.
Publicado: (2011)

Burkholderia pseudomallei Is Spatially Distributed in Soil in Northeast Thailand
por: Limmathurotsakul, Direk, et al.
Publicado: (2010)

Burkholderia pseudomallei in Water Supplies, Southern Thailand
por: Thaipadungpanit, Janjira, et al.
Publicado: (2014)

Soil Nutrient Depletion Is Associated with the Presence of Burkholderia pseudomallei
por: Hantrakun, Viriya, et al.
Publicado: (2016)

Burkholderia pseudomallei Is Genetically Diverse in Agricultural Land in Northeast Thailand
por: Wuthiekanun, Vanaporn, et al.
Publicado: (2009)

Presence of B. thailandensis and B. thailandensis expressing B. pseudomallei-like capsular polysaccharide in Thailand, and their associations with serological response to B. pseudomallei
por: Hantrakun, Viriya, et al.
Publicado: (2018)

Survival of Burkholderia pseudomallei and Pathogenic Leptospira in Cola, Beer, Energy Drinks, and Sports Drinks
por: Wuthiekanun, Vanaporn, et al.
Publicado: (2020)

No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors
por: Mailliot, Justine, et al.
Publicado: (2022)

Computational discovery and RT-PCR validation of novel Burkholderia conserved and Burkholderia pseudomallei unique sRNAs
por: Khoo, Jia-Shiun, et al.
Publicado: (2012)

Unravelling the Molecular Epidemiology and Genetic Diversity among Burkholderia pseudomallei Isolates from South India Using Multi-Locus Sequence Typing
por: Tellapragada, Chaitanya, et al.
Publicado: (2016)

Melioidosis Caused by Burkholderia pseudomallei in Drinking Water, Thailand, 2012
por: Limmathurotsakul, Direk, et al.
Publicado: (2014)

Trimethoprim/sulfamethoxazole resistance in clinical isolates of Burkholderia pseudomallei from Thailand
por: Saiprom, Natnaree, et al.
Publicado: (2015)

Survival of Burkholderia pseudomallei in Water
por: Moore, Richard A, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_ds3s1b9143pm1c014g9hntpkj7