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Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis
Cytotoxic T lymphocytes (CTLs) are highly effective serial killers capable of destroying virally infected and cancerous targets by polarized release from secretory lysosomes. Upon target contact, the CTL centrosome rapidly moves to the immunological synapse, focusing microtubule-directed release at...
Autores principales: | Stinchcombe, Jane C., Randzavola, Lyra O., Angus, Karen L., Mantell, Judith M., Verkade, Paul, Griffiths, Gillian M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691242/ https://www.ncbi.nlm.nih.gov/pubmed/26670998 http://dx.doi.org/10.1016/j.cub.2015.10.028 |
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