An Efficient Labelling Approach to Harness Backbone and Side-Chain Protons in (1)H-Detected Solid-State NMR Spectroscopy
(1)H-detection can greatly improve spectral sensitivity in biological solid-state NMR (ssNMR), thus allowing the study of larger and more complex proteins. However, the general requirement to perdeuterate proteins critically curtails the potential of (1)H-detection by the loss of aliphatic side-chai...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691318/ https://www.ncbi.nlm.nih.gov/pubmed/26555653 http://dx.doi.org/10.1002/anie.201509170 |