Nascent RNA folding mitigates transcription-associated mutagenesis

Transcription is mutagenic, in part because the R-loop formed by the binding of the nascent RNA with its DNA template exposes the nontemplate DNA strand to mutagens and primes unscheduled error-prone DNA synthesis. We hypothesize that strong folding of nascent RNA weakens R-loops and hence decreases...

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Detalles Bibliográficos
Autores principales: Chen, Xiaoshu, Yang, Jian-Rong, Zhang, Jianzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691750/
https://www.ncbi.nlm.nih.gov/pubmed/26518484
http://dx.doi.org/10.1101/gr.195164.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691750/
https://www.ncbi.nlm.nih.gov/pubmed/26518484
http://dx.doi.org/10.1101/gr.195164.115

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