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Nascent RNA folding mitigates transcription-associated mutagenesis

Transcription is mutagenic, in part because the R-loop formed by the binding of the nascent RNA with its DNA template exposes the nontemplate DNA strand to mutagens and primes unscheduled error-prone DNA synthesis. We hypothesize that strong folding of nascent RNA weakens R-loops and hence decreases...

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Detalles Bibliográficos
Autores principales:	Chen, Xiaoshu, Yang, Jian-Rong, Zhang, Jianzhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691750/ https://www.ncbi.nlm.nih.gov/pubmed/26518484 http://dx.doi.org/10.1101/gr.195164.115

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