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Peptide release promoted by methylated RF2 and ArfA in nonstop translation is achieved by an induced-fit mechanism
Here we report that the specificity of peptide release in the ribosome on a nonstop mRNA by ArfA and RF2 is achieved by an induced-fit mechanism. Using RF2 that is methylated on the glutamine of its GGQ motif (RF2(m)), we show that methylation substantially increases the rate of ArfA/RF2-catalyzed p...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691834/ https://www.ncbi.nlm.nih.gov/pubmed/26554029 http://dx.doi.org/10.1261/rna.053082.115 |