GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

Mammalian cells possess two amino acid-sensing kinases: general control nonderepressible 2 (GCN2) and mechanistic target of rapamycin complex 1 (mTORC1). Their combined effects orchestrate cellular adaptation to amino acid levels, but how their activities are coordinated remains poorly understood. H...

Descripción completa

Detalles Bibliográficos
Autores principales: Ye, Jiangbin, Palm, Wilhelm, Peng, Min, King, Bryan, Lindsten, Tullia, Li, Ming O., Koumenis, Constantinos, Thompson, Craig B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691887/
https://www.ncbi.nlm.nih.gov/pubmed/26543160
http://dx.doi.org/10.1101/gad.269324.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691887/
https://www.ncbi.nlm.nih.gov/pubmed/26543160
http://dx.doi.org/10.1101/gad.269324.115

Ejemplares similares