Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1

The apoptotic protease-activating factor 1 (Apaf-1) controls the onset of many known forms of intrinsic apoptosis in mammals. Apaf-1 exists in normal cells as an autoinhibited monomer. Upon binding to cytochrome c and dATP, Apaf-1 oligomerizes into a heptameric complex known as the apoptosome, which...

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Detalles Bibliográficos
Autores principales: Zhou, Mengying, Li, Yini, Hu, Qi, Bai, Xiao-chen, Huang, Weiyun, Yan, Chuangye, Scheres, Sjors H.W., Shi, Yigong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691890/
https://www.ncbi.nlm.nih.gov/pubmed/26543158
http://dx.doi.org/10.1101/gad.272278.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691890/
https://www.ncbi.nlm.nih.gov/pubmed/26543158
http://dx.doi.org/10.1101/gad.272278.115

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