The solution structures of native and patient monomeric human IgA1 reveal asymmetric extended structures: implications for function and IgAN disease

Native IgA1, for which no crystal structure is known, contains an O-galactosylated 23-residue hinge region that joins its Fab and Fc regions. IgA nephropathy (IgAN) is a leading cause of chronic kidney disease in developed countries. Because IgA1 in IgAN often has a poorly O-galactosylated hinge reg...

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Detalles Bibliográficos
Autores principales: Hui, Gar Kay, Wright, David W., Vennard, Owen L., Rayner, Lucy E., Pang, Melisa, Yeo, See Cheng, Gor, Jayesh, Molyneux, Karen, Barratt, Jonathan, Perkins, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692083/
https://www.ncbi.nlm.nih.gov/pubmed/26268558
http://dx.doi.org/10.1042/BJ20150612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692083/
https://www.ncbi.nlm.nih.gov/pubmed/26268558
http://dx.doi.org/10.1042/BJ20150612

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