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Type I Interferon Induced Epigenetic Regulation of Macrophages Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral Infection

Influenza A virus (IAV) is an airborne pathogen that causes significant morbidity and mortality each year. Macrophages (Mϕ) are the first immune population to encounter IAV virions in the lungs and are required to control infection. In the present study, we explored the mechanism by which cytokine s...

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Detalles Bibliográficos
Autores principales: Kroetz, Danielle N., Allen, Ronald M., Schaller, Matthew A., Cavallaro, Cleyton, Ito, Toshihiro, Kunkel, Steven L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692439/
https://www.ncbi.nlm.nih.gov/pubmed/26709698
http://dx.doi.org/10.1371/journal.ppat.1005338