Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide

Aggregation of amyloid-β (Aβ) peptides is a characteristic pathological feature of Alzheimer's disease. We have exploited the relationship between solvent exposure and intrinsic fluorescence of a single tyrosine residue, Tyr(10), in the Aβ sequence to probe structural features of the monomeric,...

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Detalles Bibliográficos
Autores principales: Aran Terol, Pablo, Kumita, Janet R., Hook, Sharon C., Dobson, Christopher M., Esbjörner, Elin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692451/
https://www.ncbi.nlm.nih.gov/pubmed/26551456
http://dx.doi.org/10.1016/j.bbrc.2015.11.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692451/
https://www.ncbi.nlm.nih.gov/pubmed/26551456
http://dx.doi.org/10.1016/j.bbrc.2015.11.018

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