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fMiRNA-192 and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma

Accumulated evidence demonstrated that long non-coding RNAs (lncRNAs) play a pivotal role in tumorigenesis. However, it is still largely unknown how these lncRNAs were regulated by small ncRNAs, such as microRNAs (miRNAs), at the post-transcriptional level. We here use lncRNA HOTTIP as an example to...

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Detalles Bibliográficos
Autores principales: Ge, Yunxia, Yan, Xiaodan, Jin, Yiguang, Yang, Xinyu, Yu, Xiang, Zhou, Liqing, Han, Sichong, Yuan, Qipeng, Yang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692503/
https://www.ncbi.nlm.nih.gov/pubmed/26710269
http://dx.doi.org/10.1371/journal.pgen.1005726