Phosphodiesterase 5a Inhibition with Adenoviral Short Hairpin RNA Benefits Infarcted Heart Partially through Activation of Akt Signaling Pathway and Reduction of Inflammatory Cytokines

INTRODUCTION: Treatment with short hairpin RNA (shRNA) interference therapy targeting phosphodiesterase 5a after myocardial infarction (MI) has been shown to mitigate post-MI heart failure. We investigated the mechanisms that underpin the beneficial effects of PDE5a inhibition through shRNA on post-...

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Detalles Bibliográficos
Autores principales: Li, Longhu, Zhao, Dong, Jin, Zhe, Zhang, Jian, Paul, Christian, Wang, Yigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692549/
https://www.ncbi.nlm.nih.gov/pubmed/26709517
http://dx.doi.org/10.1371/journal.pone.0145766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692549/
https://www.ncbi.nlm.nih.gov/pubmed/26709517
http://dx.doi.org/10.1371/journal.pone.0145766

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