Using Gene Essentiality and Synthetic Lethality Information to Correct Yeast and CHO Cell Genome-Scale Models

Essentiality (ES) and Synthetic Lethality (SL) information identify combination of genes whose deletion inhibits cell growth. This information is important for both identifying drug targets for tumor and pathogenic bacteria suppression and for flagging and avoiding gene deletions that are non-viable...

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Detalles Bibliográficos
Autores principales: Chowdhury, Ratul, Chowdhury, Anupam, Maranas, Costas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693185/
https://www.ncbi.nlm.nih.gov/pubmed/26426067
http://dx.doi.org/10.3390/metabo5040536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693185/
https://www.ncbi.nlm.nih.gov/pubmed/26426067
http://dx.doi.org/10.3390/metabo5040536

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