Cargando…
CALHM1 and its polymorphism P86L differentially control Ca(2+) homeostasis, mitogen‐activated protein kinase signaling, and cell vulnerability upon exposure to amyloid β
The mutated form of the Ca(2+) channel CALHM1 (Ca(2+) homeostasis modulator 1), P86L‐CALHM1, has been correlated with early onset of Alzheimer's disease (AD). P86L‐CALHM1 increases production of amyloid beta (Aβ) upon extracellular Ca(2+) removal and its subsequent addback. The aim of this stud...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693463/ https://www.ncbi.nlm.nih.gov/pubmed/26416646 http://dx.doi.org/10.1111/acel.12403 |