CALHM1 and its polymorphism P86L differentially control Ca(2+) homeostasis, mitogen‐activated protein kinase signaling, and cell vulnerability upon exposure to amyloid β

The mutated form of the Ca(2+) channel CALHM1 (Ca(2+) homeostasis modulator 1), P86L‐CALHM1, has been correlated with early onset of Alzheimer's disease (AD). P86L‐CALHM1 increases production of amyloid beta (Aβ) upon extracellular Ca(2+) removal and its subsequent addback. The aim of this stud...

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Detalles Bibliográficos
Autores principales: Moreno‐Ortega, Ana José, Buendia, Izaskun, Mouhid, Lamia, Egea, Javier, Lucea, Susana, Ruiz‐Nuño, Ana, López, Manuela G., Cano‐Abad, María F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693463/
https://www.ncbi.nlm.nih.gov/pubmed/26416646
http://dx.doi.org/10.1111/acel.12403

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