Growth hormone modulates hypothalamic inflammation in long‐lived pituitary dwarf mice

Mice in which the genes for growth hormone (GH) or GH receptor (GHR (−/−)) are disrupted from conception are dwarfs, possess low levels of IGF‐1 and insulin, have low rates of cancer and diabetes, and are extremely long‐lived. Median longevity is also increased in mice with deletion of hypothalamic...

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Detalles Bibliográficos
Autores principales: Sadagurski, Marianna, Landeryou, Taylor, Cady, Gillian, Kopchick, John J., List, Edward O., Berryman, Darlene E., Bartke, Andrzej, Miller, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693470/
https://www.ncbi.nlm.nih.gov/pubmed/26268661
http://dx.doi.org/10.1111/acel.12382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693470/
https://www.ncbi.nlm.nih.gov/pubmed/26268661
http://dx.doi.org/10.1111/acel.12382

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