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Growth hormone modulates hypothalamic inflammation in long‐lived pituitary dwarf mice
Mice in which the genes for growth hormone (GH) or GH receptor (GHR (−/−)) are disrupted from conception are dwarfs, possess low levels of IGF‐1 and insulin, have low rates of cancer and diabetes, and are extremely long‐lived. Median longevity is also increased in mice with deletion of hypothalamic...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693470/ https://www.ncbi.nlm.nih.gov/pubmed/26268661 http://dx.doi.org/10.1111/acel.12382 |