Inhibition of elongin C promotes longevity and protein homeostasis via HIF‐1 in C. elegans

The transcription factor hypoxia‐inducible factor 1 (HIF‐1) is crucial for responses to low oxygen and promotes longevity in Caenorhabditis elegans. We previously performed a genomewide RNA interference screen and identified many genes that act as potential negative regulators of HIF‐1. Here, we fun...

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Detalles Bibliográficos
Autores principales: Hwang, Wooseon, Artan, Murat, Seo, Mihwa, Lee, Dongyeop, Nam, Hong Gil, Lee, Seung‐Jae V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693473/
https://www.ncbi.nlm.nih.gov/pubmed/26361075
http://dx.doi.org/10.1111/acel.12390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693473/
https://www.ncbi.nlm.nih.gov/pubmed/26361075
http://dx.doi.org/10.1111/acel.12390

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