Organocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones with o-Formyl-β-nitrostyrenes

A highly diastereo- and enantioselective domino Michael/Henry reaction of 1-acetylindolin-3-ones with o-formyl-(E)-β-nitrostyrenes catalyzed by low loading of a quinine-derived amine-squaramide provides the corresponding indolin-3-one derivatives bearing four adjacent stereogenic centers in good to...

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Autores principales: Mahajan, Suruchi, Chauhan, Pankaj, Loh, Charles C. J., Uzungelis, Server, Raabe, Gerhard, Enders, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693955/
https://www.ncbi.nlm.nih.gov/pubmed/26722133
http://dx.doi.org/10.1055/s-0034-1379943
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author Mahajan, Suruchi
Chauhan, Pankaj
Loh, Charles C. J.
Uzungelis, Server
Raabe, Gerhard
Enders, Dieter
author_facet Mahajan, Suruchi
Chauhan, Pankaj
Loh, Charles C. J.
Uzungelis, Server
Raabe, Gerhard
Enders, Dieter
author_sort Mahajan, Suruchi
collection PubMed
description A highly diastereo- and enantioselective domino Michael/Henry reaction of 1-acetylindolin-3-ones with o-formyl-(E)-β-nitrostyrenes catalyzed by low loading of a quinine-derived amine-squaramide provides the corresponding indolin-3-one derivatives bearing four adjacent stereogenic centers in good to high yields and with excellent stereoselectivities.
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spelling pubmed-46939552015-12-29 Organocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones with o-Formyl-β-nitrostyrenes Mahajan, Suruchi Chauhan, Pankaj Loh, Charles C. J. Uzungelis, Server Raabe, Gerhard Enders, Dieter Synthesis (Stuttg) Article A highly diastereo- and enantioselective domino Michael/Henry reaction of 1-acetylindolin-3-ones with o-formyl-(E)-β-nitrostyrenes catalyzed by low loading of a quinine-derived amine-squaramide provides the corresponding indolin-3-one derivatives bearing four adjacent stereogenic centers in good to high yields and with excellent stereoselectivities. 2015-04-01 /pmc/articles/PMC4693955/ /pubmed/26722133 http://dx.doi.org/10.1055/s-0034-1379943 Text en License terms: CC BY-NC-ND (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Article
Mahajan, Suruchi
Chauhan, Pankaj
Loh, Charles C. J.
Uzungelis, Server
Raabe, Gerhard
Enders, Dieter
Organocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones with o-Formyl-β-nitrostyrenes
title Organocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones with o-Formyl-β-nitrostyrenes
title_full Organocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones with o-Formyl-β-nitrostyrenes
title_fullStr Organocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones with o-Formyl-β-nitrostyrenes
title_full_unstemmed Organocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones with o-Formyl-β-nitrostyrenes
title_short Organocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones with o-Formyl-β-nitrostyrenes
title_sort organocatalytic asymmetric domino michael/henry reaction of indolin-3-ones with o-formyl-β-nitrostyrenes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693955/
https://www.ncbi.nlm.nih.gov/pubmed/26722133
http://dx.doi.org/10.1055/s-0034-1379943
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