Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1

The quantitative characterization of mutational landscapes is a task of outstanding importance in evolutionary and medical biology: It is, for example, of central importance for our understanding of the phenotypic effect of mutations related to disease and antibiotic drug resistance. Here we develop...

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Detalles Bibliográficos
Autores principales: Figliuzzi, Matteo, Jacquier, Hervé, Schug, Alexander, Tenaillon, Oliver, Weigt, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693977/
https://www.ncbi.nlm.nih.gov/pubmed/26446903
http://dx.doi.org/10.1093/molbev/msv211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693977/
https://www.ncbi.nlm.nih.gov/pubmed/26446903
http://dx.doi.org/10.1093/molbev/msv211

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