Engineering an Anti-Transferrin Receptor ScFv for pH-Sensitive Binding Leads to Increased Intracellular Accumulation

The equilibrium binding affinity of receptor-ligand or antibody-antigen pairs may be modulated by protonation of histidine side-chains, and such pH-dependent mechanisms play important roles in biological systems, affecting molecular uptake and trafficking. Here, we aimed to manipulate cellular trans...

Descripción completa

Detalles Bibliográficos
Autores principales: Tillotson, Benjamin J., Goulatis, Loukas I., Parenti, Isabelle, Duxbury, Elizabeth, Shusta, Eric V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694649/
https://www.ncbi.nlm.nih.gov/pubmed/26713870
http://dx.doi.org/10.1371/journal.pone.0145820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694649/
https://www.ncbi.nlm.nih.gov/pubmed/26713870
http://dx.doi.org/10.1371/journal.pone.0145820

Ejemplares similares