Low concentrations of 5-aza-2′-deoxycytidine induce breast cancer stem cell differentiation by triggering tumor suppressor gene expression

BACKGROUND: Breast cancer stem cells (BCSCs) are considered the cause of tumor growth, multidrug resistance, metastasis, and recurrence. Therefore, differentiation therapy to reduce self-renewal of BCSCs is a promising approach. We have examined the effects of 5-aza-2′-deoxycytidine (DAC) on BCSC di...

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Detalles Bibliográficos
Autores principales: Phan, Nhan Lu-Chinh, Trinh, Ngu Van, Pham, Phuc Van
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694670/
https://www.ncbi.nlm.nih.gov/pubmed/26730203
http://dx.doi.org/10.2147/OTT.S96291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694670/
https://www.ncbi.nlm.nih.gov/pubmed/26730203
http://dx.doi.org/10.2147/OTT.S96291

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